Base pairing
From Proteopedia
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Historically, it was difficult to provide structural evidence of base pairing without solving the structure of a DNA helix fragments of ten or more base pairs. The first crystal structure of a base pair was solved by Hoogsteen in 1963 <ref>DOI:10.1107/S0365110X63002437</ref> and was not canonical (it is called a Hoogsteen pair now). A theoretical analysis of possible base pairs was difficult because the lowest energy tautomers of bases were unknown or disputed, making it impossible to distinguish possible hydrogen bond donors and acceptors. | Historically, it was difficult to provide structural evidence of base pairing without solving the structure of a DNA helix fragments of ten or more base pairs. The first crystal structure of a base pair was solved by Hoogsteen in 1963 <ref>DOI:10.1107/S0365110X63002437</ref> and was not canonical (it is called a Hoogsteen pair now). A theoretical analysis of possible base pairs was difficult because the lowest energy tautomers of bases were unknown or disputed, making it impossible to distinguish possible hydrogen bond donors and acceptors. | ||
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| + | <scene name='10/1009519/Rna_triplex/1'>RNA structures</scene> frequently contain non-canonical base pairs, <scene name='10/1009519/Rna_triplex/2'>base triples</scene> and base quadruplexes. | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 19:24, 18 November 2023
Base pairing describes how pairs of nucleobases from hydrogen bonds in a co-planar arrangement. Most base pairs show two or three hydrogen bonds. Canonical Watson-Crick base pairs are between guanine and cytosine, and between adenine and thymine (or uracil) and are common in double helical nucleic acid structures. Other base pairs also exist and have a role in forming more diverse structures.
Structure
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