Son of sevenless
From Proteopedia
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Mutations in SOS1 have been reported in Noonan syndrome and in type 1 hereditary gingival fibromatosis<ref>PMID:21787760</ref>. | Mutations in SOS1 have been reported in Noonan syndrome and in type 1 hereditary gingival fibromatosis<ref>PMID:21787760</ref>. | ||
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| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
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==3D structures of son of sevenless== | ==3D structures of son of sevenless== | ||
[[Son of sevenless 3D structures]] | [[Son of sevenless 3D structures]] | ||
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| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Son of sevenless 1; Domains - HD histone domain 1-191; DH Dbl homology 203-389; PH pleckstrin homology 443-548; REM+catalytic 601-1020 | ||
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| - | **[[3ksy]] - hSOS1 - human<br /> | ||
| - | **[[1q9c]] - hSOS1 HD <br /> | ||
| - | **[[1awe]] - hSOS1 PH - NMR <br /> | ||
| - | **[[2ii0]] - hSOS1 REM+catalytic domains<br /> | ||
| - | **[[1dbh]] - hSOS1 DH+PH domains<br /> | ||
| - | **[[1xd4]], [[1xdv]] - hSOS1 DH+PH+REM+catalytic domains<br /> | ||
| - | **[[1pms]] - mSOS1 PH (mutant) - mouse - NMR <br /> | ||
| - | *Son of sevenless 1 complex | ||
| - | **[[1bkd]] - hSOS1 REM+catalytic domains + HRas<br /> | ||
| - | **[[1xd2]] - hSOS1 REM+catalytic domains + HRas + GDP<br /> | ||
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| - | *Son of sevenless 1 homolog | ||
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| - | **[[5ovd]] - hSOS1 REM+catalytic domains (mutant)<br /> | ||
| - | **[[6scm]], [[6sfr]], [[7avi]], [[7avl]], [[7avs]], [[7avt]], [[7avu]], [[7avv]], [[7avs]] - hSOS1 REM+catalytic domains + inhibitor<br /> | ||
| - | **[[5ove]], [[5ovg]], [[5ovf]] [[5ovi]], [[5ovh]] - hSOS1 REM+catalytic domains (mutant) + inhibitor<br /> | ||
| - | **[[1nvx]], [[1nvu]] - hSOS1 REM+catalytic domains + HRas + GTP<br /> | ||
| - | **[[1nvw]], [[1nvv]] - hSOS1 REM+catalytic domains + HRas + GNP<br /> | ||
| - | **[[4us0]], [[4us1]], [[4ury]], [[4urz]], [[4us2]], [[4urv]], [[4urw]], [[4urx]] - hSOS1 REM+catalytic domains + HRas + ligand<br /> | ||
| - | **[[5wfo]], [[5wfq]], [[5fwp]], [[5fwr]] - hSOS1 REM+catalytic domains + HRas + GNP + ligand<br /> | ||
| - | **[[6d5w]], [[6d5v]], [[6d5m]], [[6bvi]], [[6bvk]], [[6bvj]], [[6bvm]], [[6bvl]], [[6cuo]], [[6d5e]], [[6d59]], [[6d56]], [[6d55]], [[6d5h]], [[6d5g]], [[6d5j]], [[6d5l]], [[6cup]], [[6cur]], [[4nym]] - hSOS1 REM+catalytic domains + HRas + GNP + activator<br /> | ||
| - | **[[4nyi]], [[4nyj]], [[6v94]], [[6v9j]], [[6v9l]], [[6v9n]], [[6v9m]], [[6v9f]] - hSOS1 REM+catalytic domains + HRas + GNP + inhibitor<br /> | ||
| - | **[[6epl]] - hSOS1 REM+catalytic domains (mutant) + KRas<br /> | ||
| - | **[[7kfz]] - hSOS1 REM+catalytic domains + KRas + GNP – Cryo EM<br /> | ||
| - | **[[6epn]], [[6epm]], [[6epp]], [[6epo]] - hSOS1 REM+catalytic domains + KRas + inhibitor<br /> | ||
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| - | *Son of sevenless 2 | ||
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| - | **[[6eie]] - hSOS2 REM+catalytic domains (mutant)<br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
</StructureSection> | </StructureSection> | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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