1oc0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1oc0.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1oc0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1oc0| PDB=1oc0 | SCENE= }}
{{STRUCTURE_1oc0| PDB=1oc0 | SCENE= }}
-
'''PLASMINOGEN ACTIVATOR INHIBITOR-1 COMPLEX WITH SOMATOMEDIN B DOMAIN OF VITRONECTIN'''
+
===PLASMINOGEN ACTIVATOR INHIBITOR-1 COMPLEX WITH SOMATOMEDIN B DOMAIN OF VITRONECTIN===
-
==Overview==
+
<!--
-
The interaction of the plasma protein vitronectin with plasminogen activator inhibitor-1 (PAI-1) is central to human health. Vitronectin binding extends the lifetime of active PAI-1, which controls hemostasis by inhibiting fibrinolysis and has also been implicated in angiogenesis. The PAI-1-vitronectin binding interaction also affects cell adhesion and motility. For these reasons, elevated PAI-1 activities are associated both with coronary thrombosis and with a poor prognosis in many cancers. Here we show the crystal structure at a resolution of 2.3 A of the complex of the somatomedin B domain of vitronectin with PAI-1. The structure of the complex explains how vitronectin binds to and stabilizes the active conformation of PAI-1. It also explains the tissue effects of PAI-1, as PAI-1 competes for and sterically blocks the interaction of vitronectin with cell surface receptors and integrins. Structural understanding of the essential biological roles of the interaction between PAI-1 and vitronectin opens the prospect of specifically designed blocking agents for the prevention of thrombosis and treatment of cancer.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12808446}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12808446 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12808446}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Proteinase inhibitor]]
[[Category: Proteinase inhibitor]]
[[Category: Serpin]]
[[Category: Serpin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:38:58 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:02:07 2008''

Revision as of 10:02, 29 July 2008

Image:1oc0.png


PDB ID 1oc0

Drag the structure with the mouse to rotate
1oc0, resolution 2.28Å ()
Related: 1a7c, 1b3k, 1c5g, 1db2, 1dvm, 1dvn, 1lj5, 9pai
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



PLASMINOGEN ACTIVATOR INHIBITOR-1 COMPLEX WITH SOMATOMEDIN B DOMAIN OF VITRONECTIN

Template:ABSTRACT PUBMED 12808446

About this Structure

1OC0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration., Zhou A, Huntington JA, Pannu NS, Carrell RW, Read RJ, Nat Struct Biol. 2003 Jul;10(7):541-4. PMID:12808446

Page seeded by OCA on Tue Jul 29 13:02:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1oc0"
Personal tools