This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1pfq
From Proteopedia
(New page: 200px<br /> <applet load="1pfq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pfq, resolution 1.90Å" /> '''crystal structure o...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1pfq.gif|left|200px]]<br /> | + | [[Image:1pfq.gif|left|200px]]<br /><applet load="1pfq" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1pfq" size=" | + | |
caption="1pfq, resolution 1.90Å" /> | caption="1pfq, resolution 1.90Å" /> | ||
'''crystal structure of human apo dipeptidyl peptidase IV / CD26'''<br /> | '''crystal structure of human apo dipeptidyl peptidase IV / CD26'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine | + | Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 A resolution. In addition, the structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrol idine has been solved, revealing the nature of the covalent interaction with the active-site serine. |
==About this Structure== | ==About this Structure== | ||
| - | 1PFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http:// | + | 1PFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFQ OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 14: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Arcy, A | + | [[Category: Arcy, A D.]] |
| - | [[Category: Dale, G | + | [[Category: Dale, G E.]] |
[[Category: Gardiner, R.]] | [[Category: Gardiner, R.]] | ||
[[Category: Oefner, C.]] | [[Category: Oefner, C.]] | ||
[[Category: Pierau, S.]] | [[Category: Pierau, S.]] | ||
| - | [[Category: Sweeney, A | + | [[Category: Sweeney, A Mac.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: mch_1]] | [[Category: mch_1]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:28:19 2008'' |
Revision as of 12:28, 21 February 2008
|
crystal structure of human apo dipeptidyl peptidase IV / CD26
Overview
Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 A resolution. In addition, the structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrol idine has been solved, revealing the nature of the covalent interaction with the active-site serine.
About this Structure
1PFQ is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.
Reference
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrol idine., Oefner C, D'Arcy A, Mac Sweeney A, Pierau S, Gardiner R, Dale GE, Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1206-12. Epub 2003, Jun 27. PMID:12832764
Page seeded by OCA on Thu Feb 21 14:28:19 2008
