1od4

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{{STRUCTURE_1od4| PDB=1od4 | SCENE= }}
{{STRUCTURE_1od4| PDB=1od4 | SCENE= }}
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'''ACETYL-COA CARBOXYLASE CARBOXYLTRANSFERASE DOMAIN'''
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===ACETYL-COA CARBOXYLASE CARBOXYLTRANSFERASE DOMAIN===
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==Overview==
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Acetyl-coenzyme A carboxylases (ACCs) are required for the biosynthesis and oxidation of long-chain fatty acids. They are targets for therapeutics against obesity and diabetes, and several herbicides function by inhibiting their carboxyltransferase (CT) domain. We determined the crystal structure of the free enzyme and the coenzyme A complex of yeast CT at 2.7 angstrom resolution and found that it comprises two domains, both belonging to the crotonase/ClpP superfamily. The active site is at the interface of a dimer. Mutagenesis and kinetic studies reveal the functional roles of conserved residues here. The herbicides target the active site of CT, providing a lead for inhibitor development against human ACCs.
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(as it appears on PubMed at http://www.pubmed.gov), where 12663926 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12663926}}
==About this Structure==
==About this Structure==
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[[Category: Ligase]]
[[Category: Ligase]]
[[Category: Obesity]]
[[Category: Obesity]]
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Revision as of 18:29, 28 July 2008

Image:1od4.png

Template:STRUCTURE 1od4

ACETYL-COA CARBOXYLASE CARBOXYLTRANSFERASE DOMAIN

Template:ABSTRACT PUBMED 12663926

About this Structure

1OD4 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase., Zhang H, Yang Z, Shen Y, Tong L, Science. 2003 Mar 28;299(5615):2064-7. PMID:12663926

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