1odv

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[[Image:1odv.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1odv| PDB=1odv | SCENE= }}
{{STRUCTURE_1odv| PDB=1odv | SCENE= }}
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'''PHOTOACTIVE YELLOW PROTEIN 1-25 DELETION MUTANT'''
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===PHOTOACTIVE YELLOW PROTEIN 1-25 DELETION MUTANT===
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==Overview==
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PAS (PER-ARNT-SIM) domains are a family of sensor protein domains involved in signal transduction in a wide range of organisms. Recent structural studies have revealed that these domains contain a structurally conserved alpha/beta-fold, whereas almost no conservation is observed at the amino acid sequence level. The photoactive yellow protein, a bacterial light sensor, has been proposed as the PAS structural prototype yet contains an N-terminal helix-turn-helix motif not found in other PAS domains. Here we describe the atomic resolution structure of a photoactive yellow protein deletion mutant lacking this motif, revealing that the PAS domain is indeed able to fold independently and is not affected by the removal of these residues. Computer simulations of currently known PAS domain structures reveal that these domains are not only structurally conserved but are also similar in their conformational flexibilities. The observed motions point to a possible common mechanism for communicating ligand binding/activation to downstream transducer proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 12639952 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12639952}}
==About this Structure==
==About this Structure==
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[[Category: Photoactivity,p-coumaric acid]]
[[Category: Photoactivity,p-coumaric acid]]
[[Category: Signalling]]
[[Category: Signalling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:43:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:12:45 2008''

Revision as of 21:12, 28 July 2008

Image:1odv.png

Template:STRUCTURE 1odv

PHOTOACTIVE YELLOW PROTEIN 1-25 DELETION MUTANT

Template:ABSTRACT PUBMED 12639952

About this Structure

1ODV is a Single protein structure of sequence from Halorhodospira halophila. Full crystallographic information is available from OCA.

Reference

PAS domains. Common structure and common flexibility., Vreede J, van der Horst MA, Hellingwerf KJ, Crielaard W, van Aalten DM, J Biol Chem. 2003 May 16;278(20):18434-9. Epub 2003 Mar 14. PMID:12639952

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