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1oed

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[[Image:1oed.jpg|left|200px]]
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{{Seed}}
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[[Image:1oed.png|left|200px]]
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{{STRUCTURE_1oed| PDB=1oed | SCENE= }}
{{STRUCTURE_1oed| PDB=1oed | SCENE= }}
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'''STRUCTURE OF ACETYLCHOLINE RECEPTOR PORE FROM ELECTRON IMAGES'''
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===STRUCTURE OF ACETYLCHOLINE RECEPTOR PORE FROM ELECTRON IMAGES===
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==Overview==
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The nicotinic acetylcholine receptor controls electrical signalling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. Here we present an atomic model of the closed pore, obtained by electron microscopy of crystalline postsynaptic membranes. The pore is shaped by an inner ring of 5 alpha-helices, which curve radially to create a tapering path for the ions, and an outer ring of 15 alpha-helices, which coil around each other and shield the inner ring from the lipids. The gate is a constricting hydrophobic girdle at the middle of the lipid bilayer, formed by weak interactions between neighbouring inner helices. When acetylcholine enters the ligand-binding domain, it triggers rotations of the protein chains on opposite sides of the entrance to the pore. These rotations are communicated through the inner helices, and open the pore by breaking the girdle apart.
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The line below this paragraph, {{ABSTRACT_PUBMED_12827192}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12827192 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12827192}}
==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Tubular crystal]]
[[Category: Tubular crystal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:44:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:04:11 2008''

Revision as of 13:04, 29 July 2008

Image:1oed.png

Template:STRUCTURE 1oed

STRUCTURE OF ACETYLCHOLINE RECEPTOR PORE FROM ELECTRON IMAGES

Template:ABSTRACT PUBMED 12827192

About this Structure

1OED is a Protein complex structure of sequences from Torpedo marmorata. Full crystallographic information is available from OCA.

Reference

Structure and gating mechanism of the acetylcholine receptor pore., Miyazawa A, Fujiyoshi Y, Unwin N, Nature. 2003 Jun 26;423(6943):949-55. PMID:12827192

Page seeded by OCA on Tue Jul 29 16:04:11 2008

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