1oey

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{{STRUCTURE_1oey| PDB=1oey | SCENE= }}
{{STRUCTURE_1oey| PDB=1oey | SCENE= }}
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'''HETERODIMER OF P40PHOX AND P67PHOX PB1 DOMAINS FROM HUMAN NADPH OXIDASE'''
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===HETERODIMER OF P40PHOX AND P67PHOX PB1 DOMAINS FROM HUMAN NADPH OXIDASE===
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==Overview==
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Maximal activation of NADPH oxidase requires formation of a complex between the p40(phox) and p67(phox) subunits via association of their PB1 domains. We have determined the crystal structure of the p40(phox)/p67(phox) PB1 heterodimer, which reveals that both domains have a beta grasp topology and that they bind in a front-to-back arrangement through conserved electrostatic interactions between an acidic OPCA motif on p40(phox) and basic residues in p67(phox). The structure enabled us to identify residues critical for heterodimerization among other members of the PB1 domain family, including the atypical protein kinase C zeta (PKC zeta) and its partners Par6 and p62 (ZIP, sequestosome). Both Par6 and p62 use their basic "back" to interact with the OPCA motif on the "front" of the PKC zeta. Besides heterodimeric interactions, some PB1 domains, like the p62 PB1, can make homotypic front-to-back arrays.
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{{ABSTRACT_PUBMED_12887891}}
==About this Structure==
==About this Structure==
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[[Category: Nadph oxidase]]
[[Category: Nadph oxidase]]
[[Category: Pb1 domain]]
[[Category: Pb1 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:45:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:14:20 2008''

Revision as of 22:14, 28 July 2008

Image:1oey.png

Template:STRUCTURE 1oey

HETERODIMER OF P40PHOX AND P67PHOX PB1 DOMAINS FROM HUMAN NADPH OXIDASE

Template:ABSTRACT PUBMED 12887891

About this Structure

1OEY is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62., Wilson MI, Gill DJ, Perisic O, Quinn MT, Williams RL, Mol Cell. 2003 Jul;12(1):39-50. PMID:12887891

Page seeded by OCA on Tue Jul 29 01:14:20 2008

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