1of5

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[[Image:1of5.gif|left|200px]]
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{{STRUCTURE_1of5| PDB=1of5 | SCENE= }}
{{STRUCTURE_1of5| PDB=1of5 | SCENE= }}
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'''CRYSTAL STRUCTURE OF MEX67-MTR2'''
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===CRYSTAL STRUCTURE OF MEX67-MTR2===
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==Overview==
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The association between Mtr2 and Mex67 is essential for the nuclear export of bulk messenger RNA in yeast. In metazoans, the analogous function is carried out by the TAP-p15 heterodimer. Whereas Mex67 and TAP are highly conserved proteins, their binding partners, Mtr2 and p15, share no sequence similarity, but are nevertheless functionally homologous. Here, we report the 2.8-A resolution crystal structure of Mtr2 in complex with the NTF2-like domain of Mex67. Mtr2 is a novel member of the NTF2-like family and interacts with Mex67, forming a complex with a similar structural architecture to that of TAP-p15. Mtr2 fulfils an analogous function to that of human p15 in maintaining the structural integrity of the heterodimer. In addition, Mtr2 presents a long internal loop, which contains residues that affect the export of the large ribosomal subunit.
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The line below this paragraph, {{ABSTRACT_PUBMED_12835756}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12835756 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12835756}}
==About this Structure==
==About this Structure==
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[[Category: Repeat]]
[[Category: Repeat]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:46:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:47:54 2008''

Revision as of 15:47, 27 July 2008

Image:1of5.png

Template:STRUCTURE 1of5

CRYSTAL STRUCTURE OF MEX67-MTR2

Template:ABSTRACT PUBMED 12835756

About this Structure

1OF5 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15., Fribourg S, Conti E, EMBO Rep. 2003 Jul;4(7):699-703. PMID:12835756

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