6jo7
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jo7 OCA], [https://pdbe.org/6jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/6jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jo7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jo7 OCA], [https://pdbe.org/6jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/6jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jo7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/MXRA8_MOUSE MXRA8_MOUSE] Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461).[UniProtKB:Q9BRK3]<ref>PMID:14603461</ref> <ref>PMID:18366072</ref> <ref>PMID:22492581</ref> <ref>PMID:29702220</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of mouse MXRA8
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Categories: Large Structures | Mus musculus | Gao F | Gao GF | Qi J | Song H | Zhao Z
