1ofu

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[[Image:1ofu.jpg|left|200px]]
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{{Seed}}
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[[Image:1ofu.png|left|200px]]
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{{STRUCTURE_1ofu| PDB=1ofu | SCENE= }}
{{STRUCTURE_1ofu| PDB=1ofu | SCENE= }}
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'''CRYSTAL STRUCTURE OF SULA:FTSZ FROM PSEUDOMONAS AERUGINOSA'''
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===CRYSTAL STRUCTURE OF SULA:FTSZ FROM PSEUDOMONAS AERUGINOSA===
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==Overview==
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SulA halts cell division in Escherichia coli by binding to the major component of the division machinery FtsZ. We have solved the crystal structure of SulA alone and in complex with FtsZ from Pseudomonas aeruginosa. SulA is expressed when the SOS response is induced. This is a mechanism to inhibit cell division and repair DNA in the event of DNA damage. FtsZ is a tubulin-like protein that forms polymers, with the active-site GTPase split across two monomers. One monomer provides the GTP-binding site and the other, through its T7 loop nucleotide hydrolysis. Our structures show that SulA is a dimer, and that SulA inhibits cell division neither by binding the nucleotide-binding site nor by inducing conformational changes in FtsZ. Instead, SulA binds the T7 loop surface of FtsZ, opposite the nucleotide-binding site, blocking polymer formation. These findings explain why GTP hydrolysis and polymer turnover are required for SulA inhibition.
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The line below this paragraph, {{ABSTRACT_PUBMED_12808143}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12808143 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12808143}}
==About this Structure==
==About this Structure==
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[[Category: Ftsz]]
[[Category: Ftsz]]
[[Category: Sula protein]]
[[Category: Sula protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:47:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:48:10 2008''

Revision as of 04:48, 29 July 2008

Image:1ofu.png

Template:STRUCTURE 1ofu

CRYSTAL STRUCTURE OF SULA:FTSZ FROM PSEUDOMONAS AERUGINOSA

Template:ABSTRACT PUBMED 12808143

About this Structure

1OFU is a Protein complex structure of sequences from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ., Cordell SC, Robinson EJ, Lowe J, Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7889-94. Epub 2003 Jun 13. PMID:12808143

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