6krz

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Current revision (05:23, 21 November 2024) (edit) (undo)
 
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== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/PAQR1_HUMAN PAQR1_HUMAN] Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).[UniProtKB:Q91VH1]<ref>PMID:12802337</ref> <ref>PMID:25855295</ref>
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[https://www.uniprot.org/uniprot/PAQR1_HUMAN PAQR1_HUMAN] Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).[UniProtKB:Q91VH1]<ref>PMID:12802337</ref> <ref>PMID:25855295</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Crystal structure of the human adiponectin receptor 1 D208A mutant

PDB ID 6krz

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