6kyk
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyk OCA], [https://pdbe.org/6kyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kyk RCSB], [https://www.ebi.ac.uk/pdbsum/6kyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyk OCA], [https://pdbe.org/6kyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kyk RCSB], [https://www.ebi.ac.uk/pdbsum/6kyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/SHAN3_MOUSE SHAN3_MOUSE] Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.<ref>PMID:21423165</ref> <ref>PMID:21558424</ref> <ref>PMID:23739967</ref> <ref>PMID:24153177</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of Shank3 NTD-ANK mutant in complex with Rap1
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