6l2k
From Proteopedia
(Difference between revisions)
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<StructureSection load='6l2k' size='340' side='right'caption='[[6l2k]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='6l2k' size='340' side='right'caption='[[6l2k]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L2K FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l2k OCA], [https://pdbe.org/6l2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l2k RCSB], [https://www.ebi.ac.uk/pdbsum/6l2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l2k ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l2k OCA], [https://pdbe.org/6l2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l2k RCSB], [https://www.ebi.ac.uk/pdbsum/6l2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l2k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ILVC_STRP2 ILVC_STRP2] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435] | ||
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Streptococcus pneumoniae D39]] | ||
[[Category: Donghyuk S]] | [[Category: Donghyuk S]] | ||
[[Category: Gyuhee K]] | [[Category: Gyuhee K]] | ||
Current revision
IlvC, a ketol-acid reductoisomerase, from Streptococcus pneumoniae_R49E
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Categories: Large Structures | Donghyuk S | Gyuhee K | Jaesook Y | Sangho L | Sumin L
