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1oht

From Proteopedia

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[[Image:1oht.gif|left|200px]]
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{{STRUCTURE_1oht| PDB=1oht | SCENE= }}
{{STRUCTURE_1oht| PDB=1oht | SCENE= }}
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'''PEPTIDOGLYCAN RECOGNITION PROTEIN-LB'''
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===PEPTIDOGLYCAN RECOGNITION PROTEIN-LB===
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==Overview==
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The family of peptidoglycan recognition proteins (PGRPs) are associated with the recognition of the peptidoglycan of microbes and subsequent activation of signaling pathways for immune response. Here the crystal structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and shows an active-site cleft with a zinc cage. Poor conservation of surface residues at the cleft predicts a widely varying individual specificity of PGRPs for molecular patterns on microbial cell walls. At the back of this cleft is a putatively conserved distinctive groove. The location and mainly hydrophobic nature of the groove indicate that the back face serves for subsequent signaling after clustering of PGRP molecules by binding to polymeric cell wall components.
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(as it appears on PubMed at http://www.pubmed.gov), where 12845326 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12845326}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Peptidoglycan-recognition protein-lb isoform 2]]
[[Category: Peptidoglycan-recognition protein-lb isoform 2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:51:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:19:44 2008''

Revision as of 15:19, 27 July 2008

Image:1oht.png

Template:STRUCTURE 1oht

PEPTIDOGLYCAN RECOGNITION PROTEIN-LB

Template:ABSTRACT PUBMED 12845326

About this Structure

1OHT is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster., Kim MS, Byun M, Oh BH, Nat Immunol. 2003 Aug;4(8):787-93. Epub 2003 Jul 6. PMID:12845326

Page seeded by OCA on Sun Jul 27 18:19:44 2008

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