1ohu

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{{Seed}}
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{{STRUCTURE_1ohu| PDB=1ohu | SCENE= }}
{{STRUCTURE_1ohu| PDB=1ohu | SCENE= }}
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'''STRUCTURE OF CAENORHABDITIS ELEGANS CED-9'''
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===STRUCTURE OF CAENORHABDITIS ELEGANS CED-9===
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==Overview==
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The interactions between B-cell lymphoma 2 (BCL-2) family members are known to be mediated through the binding of the BH3 domain of a proapoptotic member to the BH3-binding groove of an antiapoptotic member. We determined the crystal structure of antiapoptotic CED-9, which reveals a unique C-terminal helix altering the common BH3-binding region. A coexpression system to produce CED-9 in complex with proapoptotic EGL-1 enabled us to show that the binding of EGL-1 to CED-9 is extremely stable, raising the melting temperature (T(M)) of CED-9 by 25 degrees C, and that the binding surface of CED-9 extends beyond the BH3-binding region and reaches the BH4 domain. Consistently, the T(M) and a 1H-15N correlation NMR spectrum of CED-9 in complex with EGL-1 are drastically different from those of CED-9 in complex with the EGL-1 BH3 peptide. The data suggest that the recognition between other BCL-2 family members may also involve much wider protein surfaces than is previously thought.
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The line below this paragraph, {{ABSTRACT_PUBMED_12894216}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12894216 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12894216}}
==About this Structure==
==About this Structure==
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[[Category: Bcl-2 family]]
[[Category: Bcl-2 family]]
[[Category: Ced-9]]
[[Category: Ced-9]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:52:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:46:30 2008''

Revision as of 22:46, 27 July 2008

Image:1ohu.png

Template:STRUCTURE 1ohu

STRUCTURE OF CAENORHABDITIS ELEGANS CED-9

Template:ABSTRACT PUBMED 12894216

About this Structure

1OHU is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions., Woo JS, Jung JS, Ha NC, Shin J, Kim KH, Lee W, Oh BH, Cell Death Differ. 2003 Dec;10(12):1310-9. PMID:12894216

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