8ujl
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human CTDNEP1-NEP1R1 protein phosphatase complex== | |
| - | + | <StructureSection load='8ujl' size='340' side='right'caption='[[8ujl]], [[Resolution|resolution]] 1.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ujl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UJL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ujl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ujl OCA], [https://pdbe.org/8ujl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ujl RCSB], [https://www.ebi.ac.uk/pdbsum/8ujl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ujl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CNEP1_HUMAN CNEP1_HUMAN] Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.<ref>PMID:17420445</ref> <ref>PMID:22134922</ref> [https://www.uniprot.org/uniprot/H3BUT5_HUMAN H3BUT5_HUMAN] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Airola MV]] | ||
| + | [[Category: Gao S]] | ||
Revision as of 05:25, 15 May 2024
Crystal structure of human CTDNEP1-NEP1R1 protein phosphatase complex
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