8wg5

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'''Unreleased structure'''
 
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The entry 8wg5 is ON HOLD until Paper Publication
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==Cryo-EM structure of USP16 bound to H2AK119Ub nucleosome==
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<StructureSection load='8wg5' size='340' side='right'caption='[[8wg5]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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Authors: Ai, H.S., He, Z.Z., Deng, Z.H., Liu, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8wg5]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WG5 FirstGlance]. <br>
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Description: Cryo-EM structure of USP16 bound to H2AK119Ub nucleosome
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wg5 OCA], [https://pdbe.org/8wg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wg5 RCSB], [https://www.ebi.ac.uk/pdbsum/8wg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wg5 ProSAT]</span></td></tr>
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[[Category: Deng, Z.H]]
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</table>
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[[Category: Liu, L]]
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== Disease ==
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[[Category: He, Z.Z]]
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[https://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN] Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.
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[[Category: Ai, H.S]]
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== Function ==
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[https://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN] Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.<ref>PMID:10077596</ref> <ref>PMID:11753566</ref> <ref>PMID:17914355</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ai HS]]
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[[Category: Deng ZH]]
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[[Category: He ZZ]]
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[[Category: Liu L]]

Revision as of 23:17, 27 December 2023

Cryo-EM structure of USP16 bound to H2AK119Ub nucleosome

PDB ID 8wg5

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