1ok2

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[[Image:1ok2.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ok2| PDB=1ok2 | SCENE= }}
{{STRUCTURE_1ok2| PDB=1ok2 | SCENE= }}
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'''DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.'''
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===DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.===
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==Overview==
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The human complement regulator CD55 is a key molecule protecting self-cells from complement-mediated lysis. X-ray diffraction and analytical ultracentrifugation data reveal a rod-like arrangement of four short consensus repeat (SCR) domains in both the crystal and solution. The stalk linking the four SCR domains to the glycosylphosphatidylinositol anchor is extended by the addition of 11 highly charged O-glycans and positions the domains an estimated 177 A above the membrane. Mutation mapping and hydrophobic potential analysis suggest that the interaction with the convertase, and thus complement regulation, depends on the burial of a hydrophobic patch centered on the linker between SCR domains 2 and 3.
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The line below this paragraph, {{ABSTRACT_PUBMED_14734808}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14734808 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14734808}}
==About this Structure==
==About this Structure==
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[[Category: Regulator of complement]]
[[Category: Regulator of complement]]
[[Category: Short consensus repeat domain]]
[[Category: Short consensus repeat domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:56:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:46:57 2008''

Revision as of 05:46, 28 July 2008

Image:1ok2.png

Template:STRUCTURE 1ok2

DECAY ACCELERATING FACTOR (CD55): THE STRUCTURE OF AN INTACT HUMAN COMPLEMENT REGULATOR.

Template:ABSTRACT PUBMED 14734808

About this Structure

1OK2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Complement regulation at the molecular level: the structure of decay-accelerating factor., Lukacik P, Roversi P, White J, Esser D, Smith GP, Billington J, Williams PA, Rudd PM, Wormald MR, Harvey DJ, Crispin MD, Radcliffe CM, Dwek RA, Evans DJ, Morgan BP, Smith RA, Lea SM, Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1279-84. Epub 2004 Jan 20. PMID:14734808

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