1ok8

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[[Image:1ok8.gif|left|200px]]
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{{Seed}}
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[[Image:1ok8.png|left|200px]]
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{{STRUCTURE_1ok8| PDB=1ok8 | SCENE= }}
{{STRUCTURE_1ok8| PDB=1ok8 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN IN THE POSTFUSION CONFORMATION'''
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===CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN IN THE POSTFUSION CONFORMATION===
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==Overview==
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Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor and responds by conformational rearrangement to the reduced pH of an endosome. The conformational change induces fusion of viral and host-cell membranes. A three-dimensional structure of the soluble E ectodomain (sE) in its trimeric, postfusion state reveals striking differences from the dimeric, prefusion form. The elongated trimer bears three 'fusion loops' at one end, to insert into the host-cell membrane. Their structure allows us to model directly how these fusion loops interact with a lipid bilayer. The protein folds back on itself, directing its carboxy terminus towards the fusion loops. We propose a fusion mechanism driven by essentially irreversible conformational changes in E and facilitated by fusion-loop insertion into the outer bilayer leaflet. Specific features of the folded-back structure suggest strategies for inhibiting flavivirus entry.
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The line below this paragraph, {{ABSTRACT_PUBMED_14737159}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14737159 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14737159}}
==About this Structure==
==About this Structure==
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[[Category: Membrane fusion]]
[[Category: Membrane fusion]]
[[Category: Trimer]]
[[Category: Trimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:57:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 07:58:01 2008''

Revision as of 04:58, 23 July 2008

Image:1ok8.png

Template:STRUCTURE 1ok8

CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN IN THE POSTFUSION CONFORMATION

Template:ABSTRACT PUBMED 14737159

About this Structure

1OK8 is a Single protein structure of sequence from Dengue virus 2. Full crystallographic information is available from OCA.

Reference

Structure of the dengue virus envelope protein after membrane fusion., Modis Y, Ogata S, Clements D, Harrison SC, Nature. 2004 Jan 22;427(6972):313-9. PMID:14737159

Page seeded by OCA on Wed Jul 23 07:58:01 2008

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