7dyg
From Proteopedia
(Difference between revisions)
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<StructureSection load='7dyg' size='340' side='right'caption='[[7dyg]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='7dyg' size='340' side='right'caption='[[7dyg]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DYG FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WS:2-(1H-PYRAZOL-3-YL)PYRIDINE-4-CARBOXYLIC+ACID'>0WS</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WS:2-(1H-PYRAZOL-3-YL)PYRIDINE-4-CARBOXYLIC+ACID'>0WS</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dyg OCA], [https://pdbe.org/7dyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dyg RCSB], [https://www.ebi.ac.uk/pdbsum/7dyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dyg ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dyg OCA], [https://pdbe.org/7dyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dyg RCSB], [https://www.ebi.ac.uk/pdbsum/7dyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dyg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Wang T]] | [[Category: Wang T]] | ||
[[Category: Yang L]] | [[Category: Yang L]] | ||
Current revision
Histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 2-(1H-pyrazol-3-yl)isonicotinic acid
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