1omw

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[[Image:1omw.gif|left|200px]]
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{{STRUCTURE_1omw| PDB=1omw | SCENE= }}
{{STRUCTURE_1omw| PDB=1omw | SCENE= }}
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'''Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits'''
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===Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits===
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==Overview==
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The phosphorylation of heptahelical receptors by heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor kinases (GRKs) is a universal regulatory mechanism that leads to desensitization of G protein signaling and to the activation of alternative signaling pathways.We determined the crystallographic structure of bovine GRK2 in complex with G protein beta1gamma2 subunits.Our results show how the three domains of GRK2-the RGS (regulator of G protein signaling) homology, protein kinase, and pleckstrin homology domains-integrate their respective activities and recruit the enzyme to the cell membrane in an orientation that not only facilitates receptor phosphorylation, but also allows for the simultaneous inhibition of signaling by Galpha and Gbetagamma subunits.
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The line below this paragraph, {{ABSTRACT_PUBMED_12764189}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12764189 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12764189}}
==About this Structure==
==About this Structure==
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[[Category: Tesmer, J J.G.]]
[[Category: Tesmer, J J.G.]]
[[Category: Wd-40 repeat]]
[[Category: Wd-40 repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:02:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:16:38 2008''

Revision as of 23:16, 27 July 2008

Image:1omw.png

Template:STRUCTURE 1omw

Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits

Template:ABSTRACT PUBMED 12764189

About this Structure

1OMW is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma., Lodowski DT, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ, Science. 2003 May 23;300(5623):1256-62. PMID:12764189

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