1ok4
From Proteopedia
(New page: 200px<br /> <applet load="1ok4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ok4, resolution 2.10Å" /> '''ARCHAEAL FRUCTOSE 1...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OK4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermoproteus_tenax Thermoproteus tenax]] with 13P as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OK4 OCA]]. | + | 1OK4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermoproteus_tenax Thermoproteus tenax]] with 13P as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OK4 OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins., Lorentzen E, Pohl E, Zwart P, Stark A, Russell RB, Knura T, Hensel R, Siebers B, J Biol Chem. 2003 Nov 21;278(47):47253-60. Epub 2003 Aug 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12941964 12941964] | Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins., Lorentzen E, Pohl E, Zwart P, Stark A, Russell RB, Knura T, Hensel R, Siebers B, J Biol Chem. 2003 Nov 21;278(47):47253-60. Epub 2003 Aug 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12941964 12941964] | ||
| + | [[Category: Fructose-bisphosphate aldolase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermoproteus tenax]] | [[Category: Thermoproteus tenax]] | ||
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[[Category: tim barrel]] | [[Category: tim barrel]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:49:02 2007'' |
Revision as of 09:44, 30 October 2007
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ARCHAEAL FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE COVALENTLY BOUND TO THE SUBSTRATE DIHYDROXYACETONE PHOSPHATE
Overview
Fructose-1,6-bisphosphate aldolase (FBPA) catalyzes the reversible, cleavage of fructose 1,6-bisphosphate to glyceraldehyde 3-phosphate and, dihydroxyacetone phosphate in the glycolytic pathway. FBPAs from archaeal, organisms have recently been identified and characterized as a divergent, family of proteins. Here, we report the first crystal structure of an, archaeal FBPA at 1.9-A resolution. The structure of this 280-kDa protein, complex was determined using single wavelength anomalous dispersion, followed by 10-fold non-crystallographic symmetry averaging and refined to, an R-factor of 14.9% (Rfree 17.9%). The protein forms a dimer of, pentamers, consisting of subunits adopting the ubiquitous (betaalpha)8, barrel fold. Additionally, a crystal structure of the archaeal FBPA, covalently ... [(full description)]
About this Structure
1OK4 is a [Single protein] structure of sequence from [Thermoproteus tenax] with 13P as [ligand]. Active as [Fructose-bisphosphate aldolase], with EC number [4.1.2.13]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins., Lorentzen E, Pohl E, Zwart P, Stark A, Russell RB, Knura T, Hensel R, Siebers B, J Biol Chem. 2003 Nov 21;278(47):47253-60. Epub 2003 Aug 26. PMID:12941964
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