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== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/D2WXL6_9ALPC D2WXL6_9ALPC] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.[ARBA:ARBA00002928 | + | [https://www.uniprot.org/uniprot/D2WXL6_9ALPC D2WXL6_9ALPC] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.[ARBA:ARBA00002928] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.[ARBA:ARBA00025562] |
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of canine coronavirus main protease in complex with GC376
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Categories: Canine coronavirus | Large Structures | Chen Y | Chiu YF | Hou MH | Tsai CL | Wang YC | Yang CS
