This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1oo0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1oo0.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1oo0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1oo0| PDB=1oo0 | SCENE= }}
{{STRUCTURE_1oo0| PDB=1oo0 | SCENE= }}
-
'''Crystal structure of the Drosophila Mago nashi-Y14 complex'''
+
===Crystal structure of the Drosophila Mago nashi-Y14 complex===
-
==Overview==
+
<!--
-
Pre-mRNA splicing is essential for generating mature mRNA and is also important for subsequent mRNA export and quality control. The splicing history is imprinted on spliced mRNA through the deposition of a splicing-dependent multiprotein complex, the exon junction complex (EJC), at approximately 20 nucleotides upstream of exon-exon junctions. The EJC is a dynamic structure containing proteins functioning in the nuclear export and nonsense-mediated decay of spliced mRNAs. Mago nashi (Mago) and Y14 are core components of the EJC, and they form a stable heterodimer that strongly associates with spliced mRNA. Here we report a 1.85 A-resolution structure of the Drosophila Mago-Y14 complex. Surprisingly, the structure shows that the canonical RNA-binding surface of the Y14 RNA recognition motif (RRM) is involved in extensive protein-protein interactions with Mago. This unexpected finding provides important insights for understanding the molecular mechanisms of EJC assembly and RRM-mediated protein-protein interactions.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12704080}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12704080 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12704080}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Rna recognition motif]]
[[Category: Rna recognition motif]]
[[Category: Splicing]]
[[Category: Splicing]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:05:12 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:49:03 2008''

Revision as of 14:49, 28 July 2008

Image:1oo0.png

Template:STRUCTURE 1oo0

Crystal structure of the Drosophila Mago nashi-Y14 complex

Template:ABSTRACT PUBMED 12704080

About this Structure

1OO0 is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Drosophila Mago nashi-Y14 complex., Shi H, Xu RM, Genes Dev. 2003 Apr 15;17(8):971-6. PMID:12704080

Page seeded by OCA on Mon Jul 28 17:49:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1oo0"
Personal tools