We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1op5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1op5.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1op5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1op5| PDB=1op5 | SCENE= }}
{{STRUCTURE_1op5| PDB=1op5 | SCENE= }}
-
'''Crystal Structure of Fab 2G12 bound to Man9GlcNAc2'''
+
===Crystal Structure of Fab 2G12 bound to Man9GlcNAc2===
-
==Overview==
+
<!--
-
Human antibody 2G12 neutralizes a broad range of human immunodeficiency virus type 1 (HIV-1) isolates by binding an unusually dense cluster of carbohydrate moieties on the "silent" face of the gp120 envelope glycoprotein. Crystal structures of Fab 2G12 and its complexes with the disaccharide Manalpha1-2Man and with the oligosaccharide Man9GlcNAc2 revealed that two Fabs assemble into an interlocked VH domain-swapped dimer. Further biochemical, biophysical, and mutagenesis data strongly support a Fab-dimerized antibody as the prevalent form that recognizes gp120. The extraordinary configuration of this antibody provides an extended surface, with newly described binding sites, for multivalent interaction with a conserved cluster of oligomannose type sugars on the surface of gp120. The unique interdigitation of Fab domains within an antibody uncovers a previously unappreciated mechanism for high-affinity recognition of carbohydrate or other repeating epitopes on cell or microbial surfaces.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12829775}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12829775 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12829775}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Zwick, M B.]]
[[Category: Zwick, M B.]]
[[Category: Domain-swapped fab 2g12 man9glcnac2 anti-carbohydrate antibody]]
[[Category: Domain-swapped fab 2g12 man9glcnac2 anti-carbohydrate antibody]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:07:04 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:31:26 2008''

Revision as of 04:31, 29 July 2008

Image:1op5.png

Template:STRUCTURE 1op5

Crystal Structure of Fab 2G12 bound to Man9GlcNAc2

Template:ABSTRACT PUBMED 12829775

About this Structure

Full crystallographic information is available from OCA.

Reference

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition., Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, Wilson IA, Science. 2003 Jun 27;300(5628):2065-71. PMID:12829775

Page seeded by OCA on Tue Jul 29 07:31:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1op5"
Personal tools