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1op5

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{{STRUCTURE_1op5| PDB=1op5 | SCENE= }}
{{STRUCTURE_1op5| PDB=1op5 | SCENE= }}
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'''Crystal Structure of Fab 2G12 bound to Man9GlcNAc2'''
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===Crystal Structure of Fab 2G12 bound to Man9GlcNAc2===
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==Overview==
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Human antibody 2G12 neutralizes a broad range of human immunodeficiency virus type 1 (HIV-1) isolates by binding an unusually dense cluster of carbohydrate moieties on the "silent" face of the gp120 envelope glycoprotein. Crystal structures of Fab 2G12 and its complexes with the disaccharide Manalpha1-2Man and with the oligosaccharide Man9GlcNAc2 revealed that two Fabs assemble into an interlocked VH domain-swapped dimer. Further biochemical, biophysical, and mutagenesis data strongly support a Fab-dimerized antibody as the prevalent form that recognizes gp120. The extraordinary configuration of this antibody provides an extended surface, with newly described binding sites, for multivalent interaction with a conserved cluster of oligomannose type sugars on the surface of gp120. The unique interdigitation of Fab domains within an antibody uncovers a previously unappreciated mechanism for high-affinity recognition of carbohydrate or other repeating epitopes on cell or microbial surfaces.
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==About this Structure==
==About this Structure==
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[[Category: Zwick, M B.]]
[[Category: Zwick, M B.]]
[[Category: Domain-swapped fab 2g12 man9glcnac2 anti-carbohydrate antibody]]
[[Category: Domain-swapped fab 2g12 man9glcnac2 anti-carbohydrate antibody]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:07:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:31:26 2008''

Revision as of 04:31, 29 July 2008

Image:1op5.png

Template:STRUCTURE 1op5

Crystal Structure of Fab 2G12 bound to Man9GlcNAc2

Template:ABSTRACT PUBMED 12829775

About this Structure

Full crystallographic information is available from OCA.

Reference

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition., Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, Wilson IA, Science. 2003 Jun 27;300(5628):2065-71. PMID:12829775

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