1op4

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[[Image:1op4.gif|left|200px]]
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{{Seed}}
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[[Image:1op4.png|left|200px]]
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{{STRUCTURE_1op4| PDB=1op4 | SCENE= }}
{{STRUCTURE_1op4| PDB=1op4 | SCENE= }}
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'''Solution Structure of Neural Cadherin Prodomain'''
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===Solution Structure of Neural Cadherin Prodomain===
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==Overview==
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Classical cadherins mediate cell-cell adhesion through calcium-dependent homophilic interactions and are activated through cleavage of a prosequence in the late Golgi. We present here the first three-dimensional structure of a classical cadherin prosequence, solved by NMR. The prototypic prosequence of N-cadherin consists of an Ig-like domain and an unstructured C-terminal region. The folded part of the prosequence-termed prodomain-has a striking structural resemblance to cadherin "adhesive" domains that could not have been predicted from the amino acid sequence due to low sequence similarities. Our detailed structural and evolutionary analysis revealed that prodomains are distant relatives of cadherin "adhesive" domains but lack all the features known to be important for cadherin-cadherin interactions. The presence of an additional "nonadhesive" domain seems to make it impossible to engage homophilic interactions between cadherins that are necessary to activate adhesion, thus explaining the inactive state of prodomain-bearing cadherins.
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The line below this paragraph, {{ABSTRACT_PUBMED_15130472}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15130472 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15130472}}
==About this Structure==
==About this Structure==
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1OP4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OP4 OCA].
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1OP4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OP4 OCA].
==Reference==
==Reference==
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Cadherin-like domain]]
[[Category: Cadherin-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:07:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:33:11 2008''

Revision as of 18:33, 27 July 2008

Image:1op4.png

Template:STRUCTURE 1op4

Solution Structure of Neural Cadherin Prodomain

Template:ABSTRACT PUBMED 15130472

About this Structure

1OP4 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics., Koch AW, Farooq A, Shan W, Zeng L, Colman DR, Zhou MM, Structure. 2004 May;12(5):793-805. PMID:15130472

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