1opz

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[[Image:1opz.gif|left|200px]]
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{{STRUCTURE_1opz| PDB=1opz | SCENE= }}
{{STRUCTURE_1opz| PDB=1opz | SCENE= }}
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'''A core mutation affecting the folding properties of a soluble domain of the ATPase protein CopA from Bacillus subtilis'''
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===A core mutation affecting the folding properties of a soluble domain of the ATPase protein CopA from Bacillus subtilis===
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==Overview==
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The two N-terminal domains of the P-type copper ATPase, CopAa and CopAb, from Bacillus subtilis differ in their folding capabilities in vitro. Whereas CopAb has the typical betaalphabetabetaalphabeta structure and is a rigid protein, CopAa is found to be largely unfolded. A sequence analysis of the two and of orthologue homologous proteins indicates that Ser46 in CopAa may destabilise the hydrophobic core, as also confirmed through a bioinformatic energy study. CopAb has a Val in the corresponding position. The S46V and S46A mutants are found to be folded, although the latter displays multiple conformations. S46VCopAa, in both apo and copper(I) loaded forms, has very similar structural and dynamic properties with respect to CopAb, besides a different length of strand beta2 and beta4. It is intriguing that the oxygen of Thr16 is found close, though at longer than bonding distance, to copper in both domains, as it also occurs in a human orthologue domain. This study contributes to understanding the behaviour of proteins that do not properly fold in vitro. A possible biological significance of the peculiar folding behaviour of this domain is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 12888353 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12888353}}
==About this Structure==
==About this Structure==
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1OPZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPZ OCA].
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1OPZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPZ OCA].
==Reference==
==Reference==
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[[Category: Folding]]
[[Category: Folding]]
[[Category: Mutation]]
[[Category: Mutation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:08:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:04:35 2008''

Revision as of 00:04, 28 July 2008

Image:1opz.png

Template:STRUCTURE 1opz

A core mutation affecting the folding properties of a soluble domain of the ATPase protein CopA from Bacillus subtilis

Template:ABSTRACT PUBMED 12888353

About this Structure

1OPZ is a Single protein structure of sequence from Bacillus subtilis. Full experimental information is available from OCA.

Reference

A core mutation affecting the folding properties of a soluble domain of the ATPase protein CopA from Bacillus subtilis., Banci L, Bertini I, Ciofi-Baffoni S, Gonnelli L, Su XC, J Mol Biol. 2003 Aug 8;331(2):473-84. PMID:12888353

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