1okk
From Proteopedia
(New page: 200px<br /> <applet load="1okk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1okk, resolution 2.05Å" /> '''HOMO-HETERODIMERIC ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OKK is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]] with SO4, MG, GCP, BZP and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKK OCA]]. | + | 1OKK is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]] with SO4, MG, GCP, BZP and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: MNA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OKK OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: srp]] | [[Category: srp]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:49:08 2007'' |
Revision as of 09:44, 30 October 2007
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HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES
Overview
Two structurally homologous guanosine triphosphatase (GTPase) domains, interact directly during signal recognition particle (SRP)-mediated, cotranslational targeting of proteins to the membrane. The 2.05 angstrom, structure of a complex of the NG GTPase domains of Ffh and FtsY reveals a, remarkably symmetric heterodimer sequestering a composite active site that, contains two bound nucleotides. The structure explains the coordinate, activation of the two GTPases. Conformational changes coupled to formation, of their extensive interface may function allosterically to signal, formation of the targeting complex to the signal-sequence binding site and, the translocon. We propose that the complex represents a molecular "latch", and that its disengagement is regulated by completion of assembly ... [(full description)]
About this Structure
1OKK is a [Protein complex] structure of sequences from [Thermus aquaticus] with SO4, MG, GCP, BZP and EDO as [ligands]. Structure known Active Site: MNA. Full crystallographic information is available from [OCA].
Reference
Heterodimeric GTPase core of the SRP targeting complex., Focia PJ, Shepotinovskaya IV, Seidler JA, Freymann DM, Science. 2004 Jan 16;303(5656):373-7. PMID:14726591
Page seeded by OCA on Tue Oct 30 11:49:08 2007
Categories: Protein complex | Thermus aquaticus | Focia, P.J. | Freymann, D.M. | BZP | EDO | GCP | MG | SO4 | Ffh | Ftsy | Gtpase | Membrane targeting | Signal sequence recognition | Srp
