1oqd

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[[Image:1oqd.gif|left|200px]]
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{{STRUCTURE_1oqd| PDB=1oqd | SCENE= }}
{{STRUCTURE_1oqd| PDB=1oqd | SCENE= }}
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'''Crystal structure of sTALL-1 and BCMA'''
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===Crystal structure of sTALL-1 and BCMA===
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==Overview==
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The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R, were recently identified as members of the TNF superfamily, which are essential factors contributing to B-cell maturation. The functional, soluble fragment of TALL-1 (sTALL-1) forms a virus-like assembly for its proper function. Here we determine the crystal structures of sTALL-1 complexed with the extracellular domains of BCMA and BAFF-R at 2.6 and 2.5 A, respectively. The single cysteine-rich domain of BCMA and BAFF-R both have saddle-like architectures, which sit on the horseback-like surface formed by four coil regions on each individual sTALL-1 monomer. Three novel structural modules, D2, X2 and N, were revealed from the current structures. Sequence alignments, structural modelling and mutagenesis revealed that one disulphide bridge in BAFF-R is critical for determining the binding specificity of the extracellular domain eBAFF-R to TALL-1 instead of APRIL, a closely related ligand of TALL-1, which was confirmed by binding experiments in vitro.
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The line below this paragraph, {{ABSTRACT_PUBMED_12721620}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12721620 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12721620}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, G.]]
[[Category: Zhang, G.]]
[[Category: Ligand receptor complex]]
[[Category: Ligand receptor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:09:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:22:00 2008''

Revision as of 02:22, 29 July 2008

Image:1oqd.png

Template:STRUCTURE 1oqd

Crystal structure of sTALL-1 and BCMA

Template:ABSTRACT PUBMED 12721620

About this Structure

1OQD is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ligand-receptor binding revealed by the TNF family member TALL-1., Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G, Nature. 2003 May 1;423(6935):49-56. PMID:12721620

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