Tiotropium bromide
From Proteopedia
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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1013887/Cv/2'> | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1013887/Cv/2'> | ||
Tiotropium bromide, sold under the brand name Spiriva among others, is a long-acting bronchodilator (LAMA: long acting muscarinic antagonist) used in the management of chronic obstructive pulmonary disease (COPD) and asthma.<ref name="a10">[https://www.drugs.com/monograph/tiotropium.html "Tiotropium Bromide Monograph for Professionals".] Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.</ref><ref name="a11">British national formulary : BNF 76 (76th ed.). Pharmaceutical Press. 2018. pp. 247–248. ISBN 9780857113382.</ref> Specifically it is used during periods of breathing difficulty to prevent them from getting worse, rather than to prevent them from happening.<ref name="a10">[https://www.drugs.com/monograph/tiotropium.html "Tiotropium Bromide Monograph for Professionals".] Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.</ref> See also [https://en.wikipedia.org/wiki/Tiotropium_bromide Tiotropium_bromide]. | Tiotropium bromide, sold under the brand name Spiriva among others, is a long-acting bronchodilator (LAMA: long acting muscarinic antagonist) used in the management of chronic obstructive pulmonary disease (COPD) and asthma.<ref name="a10">[https://www.drugs.com/monograph/tiotropium.html "Tiotropium Bromide Monograph for Professionals".] Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.</ref><ref name="a11">British national formulary : BNF 76 (76th ed.). Pharmaceutical Press. 2018. pp. 247–248. ISBN 9780857113382.</ref> Specifically it is used during periods of breathing difficulty to prevent them from getting worse, rather than to prevent them from happening.<ref name="a10">[https://www.drugs.com/monograph/tiotropium.html "Tiotropium Bromide Monograph for Professionals".] Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.</ref> See also [https://en.wikipedia.org/wiki/Tiotropium_bromide Tiotropium_bromide]. | ||
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| + | Tiotropium is a muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, when topically applied it acts mainly on M3 muscarinic receptors[28] located on smooth muscle cells and submucosal glands. This leads to a reduction in smooth muscle contraction and mucus secretion and thus produces a bronchodilatory effect. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 12:17, 7 December 2023
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References
- ↑ 1.0 1.1 "Tiotropium Bromide Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.
- ↑ British national formulary : BNF 76 (76th ed.). Pharmaceutical Press. 2018. pp. 247–248. ISBN 9780857113382.
