1osb

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[[Image:1osb.gif|left|200px]]
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{{Seed}}
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[[Image:1osb.png|left|200px]]
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{{STRUCTURE_1osb| PDB=1osb | SCENE= }}
{{STRUCTURE_1osb| PDB=1osb | SCENE= }}
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'''Conjugative Relaxase TrwC in complex with OriT Dna. Metal-free structure.'''
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===Conjugative Relaxase TrwC in complex with OriT Dna. Metal-free structure.===
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==Overview==
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Relaxases are DNA strand transferases that catalyze the initial and final stages of DNA processing during conjugative cell-to-cell DNA transfer. Upon binding to the origin of transfer (oriT) DNA, relaxase TrwC melts the double helix. The three-dimensional structure of the relaxase domain of TrwC in complex with its cognate DNA at oriT shows a fold built on a two-layer alpha/beta sandwich, with a deep narrow cleft that houses the active site. The DNA includes one arm of an extruded cruciform, an essential feature for specific recognition. This arm is firmly embraced by the protein through a beta-ribbon positioned in the DNA major groove and a loop occupying the minor groove. It is followed by a single-stranded DNA segment that enters the active site, after a sharp U-turn forming a hydrophobic cage that traps the N-terminal methionine. Structural analysis combined with site-directed mutagenesis defines the architecture of the active site.
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The line below this paragraph, {{ABSTRACT_PUBMED_14625590}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14625590 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14625590}}
==About this Structure==
==About this Structure==
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[[Category: Dna replication]]
[[Category: Dna replication]]
[[Category: Relaxase]]
[[Category: Relaxase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:13:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:15:41 2008''

Revision as of 20:15, 28 July 2008

Image:1osb.png

Template:STRUCTURE 1osb

Conjugative Relaxase TrwC in complex with OriT Dna. Metal-free structure.

Template:ABSTRACT PUBMED 14625590

About this Structure

1OSB is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC., Guasch A, Lucas M, Moncalian G, Cabezas M, Perez-Luque R, Gomis-Ruth FX, de la Cruz F, Coll M, Nat Struct Biol. 2003 Dec;10(12):1002-10. Epub 2003 Nov 16. PMID:14625590

Page seeded by OCA on Mon Jul 28 23:15:41 2008

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