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1osp

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[[Image:1osp.gif|left|200px]]
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[[Image:1osp.png|left|200px]]
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{{STRUCTURE_1osp| PDB=1osp | SCENE= }}
{{STRUCTURE_1osp| PDB=1osp | SCENE= }}
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'''CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB'''
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===CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB===
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==Overview==
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OspA (outer surface protein A) is an abundant immunogenic lipoprotein of the Lyme disease spirochete Borrelia burgdorferi. The crystal structure of a soluble recombinant form of OspA was solved in a complex with the Fab fragment of mouse monoclonal antibody 184.1 and refined to a resolution of 1.9 A. OspA has a repetitive antiparallel beta topology with an unusual nonglobular region of "freestanding" sheet connecting globular N- and C-terminal domains. Arrays of residues with alternating charges are a predominant feature of the folding pattern in the nonglobular region. The 184.1 epitope overlaps with a well conserved surface in the N-terminal domain, and a hydrophobic cavity buried in a positively charged cleft in the C-terminal domain is a potential binding site for an unknown ligand. An exposed variable region on the C-terminal domain of OspA is predicted to be an important factor in the worldwide effectiveness of OspA-based vaccines.
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(as it appears on PubMed at http://www.pubmed.gov), where 9108020 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9108020}}
==About this Structure==
==About this Structure==
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[[Category: Borrelia burgdorferi strain b31]]
[[Category: Borrelia burgdorferi strain b31]]
[[Category: Outer surface protein a complexed with fab184 1]]
[[Category: Outer surface protein a complexed with fab184 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:14:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:56:15 2008''

Revision as of 18:56, 27 July 2008

Image:1osp.png

Template:STRUCTURE 1osp

CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN A OF BORRELIA BURGDORFERI COMPLEXED WITH A MURINE MONOCLONAL ANTIBODY FAB

Template:ABSTRACT PUBMED 9108020

About this Structure

1OSP is a Protein complex structure of sequences from Borrelia burgdorferi and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab., Li H, Dunn JJ, Luft BJ, Lawson CL, Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3584-9. PMID:9108020

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