8xa9

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m (Protected "8xa9" [edit=sysop:move=sysop])
Current revision (08:22, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xa9 is ON HOLD
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==Human MGME1 in complex with 5'-overhang DNA==
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<StructureSection load='8xa9' size='340' side='right'caption='[[8xa9]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xa9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XA9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xa9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xa9 OCA], [https://pdbe.org/8xa9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xa9 RCSB], [https://www.ebi.ac.uk/pdbsum/8xa9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xa9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MGME1_HUMAN MGME1_HUMAN] Progressive external ophthalmoplegia - myopathy - emaciation. The disease may be caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/MGME1_HUMAN MGME1_HUMAN] Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.[HAMAP-Rule:MF_03030]<ref>PMID:23313956</ref> <ref>PMID:23358826</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Mao EYC]]
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[[Category: Wu CC]]

Current revision

Human MGME1 in complex with 5'-overhang DNA

PDB ID 8xa9

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OCA

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