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1ots

From Proteopedia

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{{STRUCTURE_1ots| PDB=1ots | SCENE= }}
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'''Structure of the Escherichia coli ClC Chloride channel and Fab Complex'''
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===Structure of the Escherichia coli ClC Chloride channel and Fab Complex===
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==Overview==
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ClC channels conduct chloride (Cl-) ions across cell membranes and thereby govern the electrical activity of muscle cells and certain neurons, the transport of fluid and electrolytes across epithelia, and the acidification of intracellular vesicles. The structural basis of ClC channel gating was studied. Crystal structures of wild-type and mutant Escherichia coli ClC channels bound to a monoclonal Fab fragment reveal three Cl- binding sites within the 15-angstrom neck of an hourglass-shaped pore. The Cl- binding site nearest the extracellular solution can be occupied either by a Cl- ion or by a glutamate carboxyl group. Mutations of this glutamate residue in Torpedo ray ClC channels alter gating in electrophysiological assays. These findings reveal a form of gating in which the glutamate carboxyl group closes the pore by mimicking a Cl- ion.
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(as it appears on PubMed at http://www.pubmed.gov), where 12649487 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12649487}}
==About this Structure==
==About this Structure==
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[[Category: Clc chloride channel]]
[[Category: Clc chloride channel]]
[[Category: Fab complex]]
[[Category: Fab complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:47:28 2008''

Revision as of 04:47, 28 July 2008

Image:1ots.png


PDB ID 1ots

Drag the structure with the mouse to rotate
1ots, resolution 2.51Å ()
Ligands:
Gene: ERIC OR B0155 (Escherichia coli)
Related: 1ott, 1otu
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structure of the Escherichia coli ClC Chloride channel and Fab Complex

Template:ABSTRACT PUBMED 12649487

About this Structure

1OTS is a Single protein structure of sequence from Escherichia coli and Mus musculus. Full crystallographic information is available from OCA.

Reference

Gating the selectivity filter in ClC chloride channels., Dutzler R, Campbell EB, MacKinnon R, Science. 2003 Apr 4;300(5616):108-12. Epub 2003 Mar 20. PMID:12649487

Page seeded by OCA on Mon Jul 28 07:47:28 2008

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