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1otz

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[[Image:1otz.gif|left|200px]]
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{{STRUCTURE_1otz| PDB=1otz | SCENE= }}
{{STRUCTURE_1otz| PDB=1otz | SCENE= }}
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'''Crystal structure of the BAFF-BAFF-R complex (part I)'''
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===Crystal structure of the BAFF-BAFF-R complex (part I)===
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==Overview==
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B-cell activating factor (BAFF) is a key regulator of B-lymphocyte development. Its biological role is mediated by the specific receptors BCMA, TACI and BAFF-R. We have determined the crystal structure of the extracellular domain of BAFF-R bound to BAFF at a resolution of 3.3 A. The cysteine-rich domain (CRD) of the BAFF-R extracellular domain adopts a beta-hairpin structure and binds to the virus-like BAFF cage in a 1:1 molar ratio. The conserved DxL motif of BAFF-R is located on the tip of the beta-turn and is indispensable in the binding of BAFF. The crystal structure shows that a unique dimeric contact occurs between the BAFF-R monomers in the virus-like cage complex. The extracellular domain of TACI contains two CRDs, both of which contain the DxL motif. Modeling of TACI-BAFF complex suggests that both CDRs simultaneously interact with the BAFF dimer in the virus-like cage.
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The line below this paragraph, {{ABSTRACT_PUBMED_12715002}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12715002 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12715002}}
==About this Structure==
==About this Structure==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Cytokine]]
[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:16:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:09:13 2008''

Revision as of 15:09, 27 July 2008

Image:1otz.png

Template:STRUCTURE 1otz

Crystal structure of the BAFF-BAFF-R complex (part I)

Template:ABSTRACT PUBMED 12715002

About this Structure

1OTZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation., Kim HM, Yu KS, Lee ME, Shin DR, Kim YS, Paik SG, Yoo OJ, Lee H, Lee JO, Nat Struct Biol. 2003 May;10(5):342-8. PMID:12715002

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