1ouj

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{{STRUCTURE_1ouj| PDB=1ouj | SCENE= }}
{{STRUCTURE_1ouj| PDB=1ouj | SCENE= }}
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'''CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V99A MUTANT'''
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===CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V99A MUTANT===
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==Overview==
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The physicochemical properties of an amyloidogenic mutant human lysozyme (Ile56Thr) were examined in order to elucidate the mechanism of amyloid formation. The crystal structure of the mutant protein was the same as the wild-type structure, except that the hydroxyl group of the introduced Thr56 formed a hydrogen bond with a water molecule in the interior of the protein. The other physicochemical properties of the mutant protein in the native state were not different from those of the wild-type protein. However, the equilibrium and kinetic stabilities of the mutant protein were remarkably decreased due to the introduction of a polar residue (Thr) in the interior of the molecule. It can be concluded that the amyloid formation of the mutant human lysozyme is due to a tendency to favor (partly or/and completely) denatured structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 9010773 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9010773}}
==About this Structure==
==About this Structure==
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[[Category: Disease mutation]]
[[Category: Disease mutation]]
[[Category: Signal]]
[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:17:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:13:34 2008''

Revision as of 03:13, 29 July 2008

Image:1ouj.png

Template:STRUCTURE 1ouj

CONTRIBUTION OF HYDROPHOBIC RESIDUES TO THE STABILITY OF HUMAN LYSOZYME: X-RAY STRUCTURE OF THE V99A MUTANT

Template:ABSTRACT PUBMED 9010773

About this Structure

1OUJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure, stability, and folding process of amyloidogenic mutant human lysozyme., Funahashi J, Takano K, Ogasahara K, Yamagata Y, Yutani K, J Biochem. 1996 Dec;120(6):1216-23. PMID:9010773

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