1ouw

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{{STRUCTURE_1ouw| PDB=1ouw | SCENE= }}
{{STRUCTURE_1ouw| PDB=1ouw | SCENE= }}
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'''Crystal structure of Calystegia sepium agglutinin'''
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===Crystal structure of Calystegia sepium agglutinin===
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==Overview==
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The high number of quaternary structures observed for lectins highlights the important role of these oligomeric assemblies during carbohydrate recognition events. Although a large diversity in the mode of association of lectin subunits is frequently observed, the oligomeric assemblies of plant lectins display small variations within a single family. The crystal structure of the mannose-binding jacalin-related lectin from Calystegia sepium (Calsepa) has been determined at 1.37-A resolution. Calsepa exhibits the same beta-prism fold as identified previously for other members of the family, but the shape and the hydrophobic character of its carbohydrate-binding site is unlike that of other members, consistent with surface plasmon resonance analysis showing a preference for methylated sugars. Calsepa reveals a novel dimeric assembly markedly dissimilar to those described earlier for Heltuba and jacalin but mimics the canonical 12-stranded beta-sandwich dimer found in legume lectins. The present structure exemplifies the adaptability of the beta-prism building block in the evolution of plant lectins and highlights the biological role of these quaternary structures for carbohydrate recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_14561768}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14561768 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14561768}}
==About this Structure==
==About this Structure==
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[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Mannose-binding]]
[[Category: Mannose-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:18:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:44:25 2008''

Revision as of 04:44, 28 July 2008

Image:1ouw.png

Template:STRUCTURE 1ouw

Crystal structure of Calystegia sepium agglutinin

Template:ABSTRACT PUBMED 14561768

About this Structure

1OUW is a Single protein structure of sequence from Calystegia sepium. Full crystallographic information is available from OCA.

Reference

The crystal structure of the Calystegia sepium agglutinin reveals a novel quaternary arrangement of lectin subunits with a beta-prism fold., Bourne Y, Roig-Zamboni V, Barre A, Peumans WJ, Astoul CH, Van Damme EJ, Rouge P, J Biol Chem. 2004 Jan 2;279(1):527-33. Epub 2003 Oct 15. PMID:14561768

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