1ow1

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{{STRUCTURE_1ow1| PDB=1ow1 | SCENE= }}
{{STRUCTURE_1ow1| PDB=1ow1 | SCENE= }}
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'''Crystal structure of the SPOC domain of the human transcriptional corepressor, SHARP.'''
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===Crystal structure of the SPOC domain of the human transcriptional corepressor, SHARP.===
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==Overview==
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Spen proteins regulate the expression of key transcriptional effectors in diverse signaling pathways. They are large proteins characterized by N-terminal RNA-binding motifs and a highly conserved C-terminal SPOC domain. The specific biological role of the SPOC domain (Spen paralog and ortholog C-terminal domain), and hence, the common function of Spen proteins, has been unclear to date. The Spen protein, SHARP (SMRT/HDAC1-associated repressor protein), was identified as a component of transcriptional repression complexes in both nuclear receptor and Notch/RBP-Jkappa signaling pathways. We have determined the 1.8 A crystal structure of the SPOC domain from SHARP. This structure shows that essentially all of the conserved surface residues map to a positively charged patch. Structure-based mutational analysis indicates that this conserved region is responsible for the interaction between SHARP and the universal transcriptional corepressor SMRT/NCoR (silencing mediator for retinoid and thyroid receptors/nuclear receptor corepressor. We demonstrate that this interaction involves a highly conserved acidic motif at the C terminus of SMRT/NCoR. These findings suggest that the conserved function of the SPOC domain is to mediate interaction with SMRT/NCoR corepressors, and that Spen proteins play an essential role in the repression complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 12897056 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12897056}}
==About this Structure==
==About this Structure==
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[[Category: Beta-alpha-barrel]]
[[Category: Beta-alpha-barrel]]
[[Category: Spoc domain]]
[[Category: Spoc domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:20:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:20:47 2008''

Revision as of 12:20, 29 July 2008

Image:1ow1.png

Template:STRUCTURE 1ow1

Crystal structure of the SPOC domain of the human transcriptional corepressor, SHARP.

Template:ABSTRACT PUBMED 12897056

About this Structure

1OW1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling., Ariyoshi M, Schwabe JW, Genes Dev. 2003 Aug 1;17(15):1909-20. PMID:12897056

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