1owf

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[[Image:1owf.gif|left|200px]]
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{{Seed}}
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[[Image:1owf.png|left|200px]]
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{{STRUCTURE_1owf| PDB=1owf | SCENE= }}
{{STRUCTURE_1owf| PDB=1owf | SCENE= }}
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'''Crystal structure of a mutant IHF (BetaE44A) complexed with the native H' Site'''
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===Crystal structure of a mutant IHF (BetaE44A) complexed with the native H' Site===
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==Overview==
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Integration host factor (IHF) is a DNA-bending protein that recognizes its cognate sites through indirect readout. Previous studies have shown that binding of wild-type (WT)-IHF is disrupted by a T to A mutation at the center position of a conserved TTR motif in its binding site, and that substitution of betaGlu44 with Ala prevented IHF from discriminating between A and T at this position. We have determined the crystal structures and relative binding affinities for all combinations of WT-IHF and IHF-betaGlu44Ala bound to the WT and mutant DNAs. Comparison of these structures reveals that DNA twist plays a major role in DNA recognition by IHF, and that this geometric parameter is dependent on the dinucleotide step and not on the bound IHF variant.
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The line below this paragraph, {{ABSTRACT_PUBMED_12842466}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12842466 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12842466}}
==About this Structure==
==About this Structure==
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[[Category: Minor groove]]
[[Category: Minor groove]]
[[Category: Protein-dna recognition]]
[[Category: Protein-dna recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:21:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:25:16 2008''

Revision as of 20:25, 27 July 2008

Image:1owf.png

Template:STRUCTURE 1owf

Crystal structure of a mutant IHF (BetaE44A) complexed with the native H' Site

Template:ABSTRACT PUBMED 12842466

About this Structure

1OWF is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Integration host factor: putting a twist on protein-DNA recognition., Lynch TW, Read EK, Mattis AN, Gardner JF, Rice PA, J Mol Biol. 2003 Jul 11;330(3):493-502. PMID:12842466

Page seeded by OCA on Sun Jul 27 23:25:16 2008

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