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1owr

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[[Image:1owr.gif|left|200px]]
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{{STRUCTURE_1owr| PDB=1owr | SCENE= }}
{{STRUCTURE_1owr| PDB=1owr | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN NFAT1 BOUND MONOMERICALLY TO DNA'''
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===CRYSTAL STRUCTURE OF HUMAN NFAT1 BOUND MONOMERICALLY TO DNA===
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==Overview==
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The nuclear factor of activated T cells (NFAT) is a calcium-dependent transcription factor that cooperates with a myriad of partner transcription factors to regulate distinct transcription programs. Transcription activation by NFAT without the cooperation of co-stimulatory signals in lymphocytes can also impose a genetic program of anergy. Although the ternary NFAT1/Fos-Jun/DNA complex has been structurally characterized, how NFAT1 recognizes DNA in the absence of cooperative partners and how such a binary NFAT/DNA complex may lead to the assembly of distinct high-order NFAT transcription complexes are still poorly understood. We have determined the crystal structure of the entire Rel homology region (RHR) of human NFAT1 (NFATc2) bound to DNA as a monomer. We also present footprinting evidence that corroborates the protein-DNA contacts observed in the crystal structure. Our structural and biochemical studies reveal the mechanism by which the monomeric Rel protein NFAT recognizes its cognate DNA site. A remarkable feature of the binary NFAT/DNA complex is the conformational flexibility exhibited by NFAT1 in the four independent copies of the NFAT/DNA complex in the crystal structure, which may reflect a mechanism by which NFAT1 interacts with a variety of protein partners as it mediates disparate biological responses.
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The line below this paragraph, {{ABSTRACT_PUBMED_14643663}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14643663 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14643663}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Pseudo-continuous]]
[[Category: Pseudo-continuous]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:22:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:44:36 2008''

Revision as of 05:44, 28 July 2008

Image:1owr.png

Template:STRUCTURE 1owr

CRYSTAL STRUCTURE OF HUMAN NFAT1 BOUND MONOMERICALLY TO DNA

Template:ABSTRACT PUBMED 14643663

About this Structure

1OWR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of NFAT bound to DNA as a monomer., Stroud JC, Chen L, J Mol Biol. 2003 Dec 12;334(5):1009-22. PMID:14643663

Page seeded by OCA on Mon Jul 28 08:44:36 2008

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