1ox9

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[[Image:1ox9.gif|left|200px]]
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{{STRUCTURE_1ox9| PDB=1ox9 | SCENE= }}
{{STRUCTURE_1ox9| PDB=1ox9 | SCENE= }}
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'''Crystal structure of SspB-ssrA complex'''
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===Crystal structure of SspB-ssrA complex===
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==Overview==
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In prokaryotes, incomplete or misfolded polypeptides emanating from a stalled ribosome are marked for degradation by the addition of an 11 residue peptide (AANDENYALAA) to their C terminus. Substrates containing this conserved degradation signal, the SsrA tag, are targeted to specific proteases including ClpXP and ClpAP. SspB was originally characterized as a stringent starvation protein and has been found to bind specifically to SsrA-tagged proteins and to enhance recognition of these proteins by the ClpXP degradation machine. Here, we report the crystal structures of SspB alone and in complex with an SsrA peptide. Unexpectedly, SspB exhibits a fold found in Sm-family RNA binding proteins. The dimeric SspB structures explain the key determinants for recognition of the SsrA tag and define a hydrophobic channel that may bind unfolded substrates.
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(as it appears on PubMed at http://www.pubmed.gov), where 12887894 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12887894}}
==About this Structure==
==About this Structure==
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[[Category: Song, H K.]]
[[Category: Song, H K.]]
[[Category: Sspb-ssra]]
[[Category: Sspb-ssra]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:04:43 2008''

Revision as of 03:04, 29 July 2008

Image:1ox9.png

Template:STRUCTURE 1ox9

Crystal structure of SspB-ssrA complex

Template:ABSTRACT PUBMED 12887894

About this Structure

1OX9 is a Single protein structure of sequence from Escherichia coli o157:h7. Full crystallographic information is available from OCA.

Reference

Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine., Song HK, Eck MJ, Mol Cell. 2003 Jul;12(1):75-86. PMID:12887894

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