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1oxa

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[[Image:1oxa.jpg|left|200px]]
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{{STRUCTURE_1oxa| PDB=1oxa | SCENE= }}
{{STRUCTURE_1oxa| PDB=1oxa | SCENE= }}
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'''CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)'''
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===CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)===
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==Overview==
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Cytochrome P450eryF catalyzes the 6S-hydroxylation of 6-deoxyerythronolide B, the initial reaction in a multistep pathway to convert 6-deoxyerythronolide B into the antibiotic, erythromycin. The overall structure of P450eryF is similar to that of P450cam but differs in the exact positioning of several alpha-helices. The largest difference occurs in the B' helix and results in the enlargement of the substrate-binding pocket of P450eryF. The substrate is positioned with the macrolide ring perpendicular to the haem plane and contacts seven hydrophobic residues and three solvent molecules. The substrate participates in a network of hydrogen bonds that may provide a proton shuttle pathway in the oxygen cleavage reaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 7749919 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7749919}}
==About this Structure==
==About this Structure==
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[[Category: Cupp-Vickery, J R.]]
[[Category: Cupp-Vickery, J R.]]
[[Category: Poulos, T L.]]
[[Category: Poulos, T L.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:13:10 2008''

Revision as of 02:13, 28 July 2008

Image:1oxa.png

Template:STRUCTURE 1oxa

CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)

Template:ABSTRACT PUBMED 7749919

About this Structure

1OXA is a Single protein structure of sequence from Saccharopolyspora erythraea. Full crystallographic information is available from OCA.

Reference

Structure of cytochrome P450eryF involved in erythromycin biosynthesis., Cupp-Vickery JR, Poulos TL, Nat Struct Biol. 1995 Feb;2(2):144-53. PMID:7749919

Page seeded by OCA on Mon Jul 28 05:13:10 2008

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