1oxb

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[[Image:1oxb.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1oxb| PDB=1oxb | SCENE= }}
{{STRUCTURE_1oxb| PDB=1oxb | SCENE= }}
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'''Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)'''
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===Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)===
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==Overview==
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In Saccharomyces cerevisiae, a branched multistep phosphorelay signaling pathway regulates cellular adaptation to hyperosmotic stress. YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7). These four proteins are evolutionarily related to the well-characterized "two-component" regulatory proteins from bacteria. Although structural information is available for many two-component signaling proteins, there are very few examples of complexes between interacting phosphorelay partners. Here we report the first crystal structure of a prototypical monomeric histidine-containing phosphotransfer (HPt) protein YPD1 in complex with its upstream phosphodonor, the response regulator domain associated with SLN1.
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(as it appears on PubMed at http://www.pubmed.gov), where 14656441 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14656441}}
==About this Structure==
==About this Structure==
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[[Category: Two-component signaling protein]]
[[Category: Two-component signaling protein]]
[[Category: Ypd1p]]
[[Category: Ypd1p]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:17:26 2008''

Revision as of 16:17, 27 July 2008

Image:1oxb.png

Template:STRUCTURE 1oxb

Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)

Template:ABSTRACT PUBMED 14656441

About this Structure

1OXB is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The yeast YPD1/SLN1 complex: insights into molecular recognition in two-component signaling systems., Xu Q, Porter SW, West AH, Structure. 2003 Dec;11(12):1569-81. PMID:14656441

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