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1oy8

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[[Image:1oy8.jpg|left|200px]]
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[[Image:1oy8.png|left|200px]]
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==Overview==
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{{ABSTRACT_12738864}}
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Multidrug efflux pumps cause serious problems in cancer chemotherapy and treatment of bacterial infections. Yet high-resolution structures of ligand transporter complexes have previously been unavailable. We obtained x-ray crystallographic structures of the trimeric AcrB pump from Escherichia coli with four structurally diverse ligands. The structures show that three molecules of ligands bind simultaneously to the extremely large central cavity of 5000 cubic angstroms, primarily by hydrophobic, aromatic stacking and van der Waals interactions. Each ligand uses a slightly different subset of AcrB residues for binding. The bound ligand molecules often interact with each other, stabilizing the binding.
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==About this Structure==
==About this Structure==
1OY8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY8 OCA].
1OY8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY8 OCA].
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==Reference==
 
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Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump., Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr, Science. 2003 May 9;300(5621):976-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12738864 12738864]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Zgurskaya, H I.]]
[[Category: Zgurskaya, H I.]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:25:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:48:25 2008''

Revision as of 14:48, 26 June 2008

Image:1oy8.png

Template:STRUCTURE 1oy8

Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump


Template:ABSTRACT 12738864

About this Structure

1OY8 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:48:25 2008

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