1oyp

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{{STRUCTURE_1oyp| PDB=1oyp | SCENE= }}
{{STRUCTURE_1oyp| PDB=1oyp | SCENE= }}
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'''Crystal Structure of the phosphorolytic exoribonuclease RNase PH from Bacillus subtilis'''
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===Crystal Structure of the phosphorolytic exoribonuclease RNase PH from Bacillus subtilis===
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==Overview==
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RNase PH is a member of the family of phosphorolytic 3' --&gt; 5' exoribonucleases that also includes polynucleotide phosphorylase (PNPase). RNase PH is involved in the maturation of tRNA precursors and especially important for removal of nucleotide residues near the CCA acceptor end of the mature tRNAs. Wild-type and triple mutant R68Q-R73Q-R76Q RNase PH from Bacillus subtilis have been crystallized and the structures determined by X-ray diffraction to medium resolution. Wild-type and triple mutant RNase PH crystallize as a hexamer and dimer, respectively. The structures contain a rare left-handed beta alpha beta-motif in the N-terminal portion of the protein. This motif has also been identified in other enzymes involved in RNA metabolism. The RNase PH structure and active site can, despite low sequence similarity, be overlayed with the N-terminal core of the structure and active site of Streptomyces antibioticus PNPase. The surface of the RNase PH dimer fit the shape of a tRNA molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 14767080 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14767080}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Trna processing]]
[[Category: Trna processing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:26:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:40:31 2008''

Revision as of 23:40, 28 July 2008

Image:1oyp.png

Template:STRUCTURE 1oyp

Crystal Structure of the phosphorolytic exoribonuclease RNase PH from Bacillus subtilis

Template:ABSTRACT PUBMED 14767080

About this Structure

1OYP is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of the phosphorolytic exoribonuclease RNase PH from Bacillus subtilis and implications for its quaternary structure and tRNA binding., Harlow LS, Kadziola A, Jensen KF, Larsen S, Protein Sci. 2004 Mar;13(3):668-77. Epub 2004 Feb 6. PMID:14767080

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