1oyu

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{{STRUCTURE_1oyu| PDB=1oyu | SCENE= }}
{{STRUCTURE_1oyu| PDB=1oyu | SCENE= }}
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'''Long-Distance conformational changes in a protein engineered by modulated sequence duplication'''
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===Long-Distance conformational changes in a protein engineered by modulated sequence duplication===
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==Overview==
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There are few, if any, known instances in which a biological signal is transmitted via a large conformational change through the body of a protein. We describe here a mutant of T4 lysozyme that was engineered to permit structural change at a distance. The design uses a tandem sequence repeat that makes it possible to transmit large-scale structural changes from one end of an alpha-helix to the other over a distance of 17-25 A. The method should be of general applicability and may make it possible to introduce a mutation at one site in a protein that will induce large-scale changes in the structure at a spatially remote site.
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(as it appears on PubMed at http://www.pubmed.gov), where 12869697 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12869697}}
==About this Structure==
==About this Structure==
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[[Category: Sequence duplication]]
[[Category: Sequence duplication]]
[[Category: Tandem repeat]]
[[Category: Tandem repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:26:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:26:13 2008''

Revision as of 16:26, 28 July 2008

Image:1oyu.png

Template:STRUCTURE 1oyu

Long-Distance conformational changes in a protein engineered by modulated sequence duplication

Template:ABSTRACT PUBMED 12869697

About this Structure

1OYU is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Long-distance conformational changes in a protein engineered by modulated sequence duplication., Sagermann M, Gay L, Matthews BW, Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9191-5. Epub 2003 Jul 17. PMID:12869697

Page seeded by OCA on Mon Jul 28 19:26:13 2008

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