1oyw

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[[Image:1oyw.gif|left|200px]]
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{{Seed}}
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[[Image:1oyw.png|left|200px]]
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{{STRUCTURE_1oyw| PDB=1oyw | SCENE= }}
{{STRUCTURE_1oyw| PDB=1oyw | SCENE= }}
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'''Structure of the RecQ Catalytic Core'''
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===Structure of the RecQ Catalytic Core===
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==Overview==
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RecQ family helicases catalyze critical genome maintenance reactions in bacterial and eukaryotic cells, playing key roles in several DNA metabolic processes. Mutations in recQ genes are linked to genome instability and human disease. To define the physical basis of RecQ enzyme function, we have determined a 1.8 A resolution crystal structure of the catalytic core of Escherichia coli RecQ in its unbound form and a 2.5 A resolution structure of the core bound to the ATP analog ATPgammaS. The RecQ core comprises four conserved subdomains; two of these combine to form its helicase region, while the others form unexpected Zn(2+)-binding and winged-helix motifs. The structures reveal the molecular basis of missense mutations that cause Bloom's syndrome, a human RecQ-associated disease. Finally, based on findings from the structures, we propose a mechanism for RecQ activity that could explain its functional coordination with topoisomerase III.
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The line below this paragraph, {{ABSTRACT_PUBMED_14517231}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14517231 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14517231}}
==About this Structure==
==About this Structure==
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[[Category: Recq]]
[[Category: Recq]]
[[Category: Winged helix]]
[[Category: Winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:26:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:42:30 2008''

Revision as of 05:42, 28 July 2008

Image:1oyw.png

Template:STRUCTURE 1oyw

Structure of the RecQ Catalytic Core

Template:ABSTRACT PUBMED 14517231

About this Structure

1OYW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

High-resolution structure of the E.coli RecQ helicase catalytic core., Bernstein DA, Zittel MC, Keck JL, EMBO J. 2003 Oct 1;22(19):4910-21. PMID:14517231

Page seeded by OCA on Mon Jul 28 08:42:30 2008

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