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1p0p

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{{STRUCTURE_1p0p| PDB=1p0p | SCENE= }}
{{STRUCTURE_1p0p| PDB=1p0p | SCENE= }}
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'''Crystal structure of soman-aged human butyryl cholinesterase in complex with the substrate analog butyrylthiocholine'''
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===Crystal structure of soman-aged human butyryl cholinesterase in complex with the substrate analog butyrylthiocholine===
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==Overview==
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Cholinesterases are among the most efficient enzymes known. They are divided into two groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, and butyrylcholinesterase of unknown function. Several crystal structures of the former have shown that the active site is located at the bottom of a deep and narrow gorge, raising the question of how substrate and products enter and leave. Human butyrylcholinesterase (BChE) has attracted attention because it can hydrolyze toxic esters such as cocaine or scavenge organophosphorus pesticides and nerve agents. Here we report the crystal structures of several recombinant truncated human BChE complexes and conjugates and provide a description for mechanistically relevant non-productive substrate and product binding. As expected, the structure of BChE is similar to a previously published theoretical model of this enzyme and to the structure of Torpedo acetylcholinesterase. The main difference between the experimentally determined BChE structure and its model is found at the acyl binding pocket that is significantly bigger than expected. An electron density peak close to the catalytic Ser(198) has been modeled as bound butyrate.
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The line below this paragraph, {{ABSTRACT_PUBMED_12869558}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12869558 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12869558}}
==About this Structure==
==About this Structure==
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[[Category: Serine hydrolase]]
[[Category: Serine hydrolase]]
[[Category: Soman]]
[[Category: Soman]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:32:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:22:02 2008''

Revision as of 18:22, 28 July 2008

Image:1p0p.png

Template:STRUCTURE 1p0p

Crystal structure of soman-aged human butyryl cholinesterase in complex with the substrate analog butyrylthiocholine

Template:ABSTRACT PUBMED 12869558

About this Structure

1P0P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products., Nicolet Y, Lockridge O, Masson P, Fontecilla-Camps JC, Nachon F, J Biol Chem. 2003 Oct 17;278(42):41141-7. Epub 2003 Jul 17. PMID:12869558

Page seeded by OCA on Mon Jul 28 21:22:02 2008

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