1p0u

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{{STRUCTURE_1p0u| PDB=1p0u | SCENE= }}
{{STRUCTURE_1p0u| PDB=1p0u | SCENE= }}
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'''Sheared G/C Base Pair'''
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===Sheared G/C Base Pair===
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==Overview==
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Stable DNA loop structures closed by a novel G.C base-pair have been determined for the single-residue d(GXC) loops (X=A, T, G or C) in low-salt solution by high-resolution nuclear magnetic resonance (NMR) techniques. The closing G.C base-pair in these loops is not of the canonical Watson-Crick type, but adopts instead a unique sheared-type (trans Watson-Crick/sugar-edge) pairing, like those occurring in the sheared mismatched G.A or A.C base-pair, to draw the two opposite strands together. The cytidine residue in the closing base-pair is transformed into the rare syn domain to form two H-bonds with the guanine base and to prevent the steric clash between the G 2NH(2) and the C H-5 protons. Besides, the sugar pucker of the syn cytidine is still located in the regular C2'-endo domain, unlike the C3'-endo domain adopted for the pyrimidines of the out-of-alternation left-handed Z-DNA structure. The facile formation of the compact d(GXC) loops closed by a unique sheared-type G(anti).C(syn) base-pair demonstrates the great potential of the single-stranded d(GXC) triplet repeats to fold into stable hairpins.
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{{ABSTRACT_PUBMED_12758081}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0U OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0U OCA].
==Reference==
==Reference==
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[[Category: Single-residue loop]]
[[Category: Single-residue loop]]
[[Category: Syn cytidine]]
[[Category: Syn cytidine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:32:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:56:55 2008''

Revision as of 03:57, 28 July 2008

Image:1p0u.png

Template:STRUCTURE 1p0u

Sheared G/C Base Pair

Template:ABSTRACT PUBMED 12758081

About this Structure

Full experimental information is available from OCA.

Reference

Sheared-type G(anti).C(syn) base-pair: a unique d(GXC) loop closure motif., Chin KH, Chou SH, J Mol Biol. 2003 May 30;329(2):351-61. PMID:12758081

Page seeded by OCA on Mon Jul 28 06:56:55 2008

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